The aim of the present investigation was to develop microsponge gel of ciclopirox for sustained release action. Microsponge containing Ciclopirox Olamine drug with different proportions of EudragitRS 100, EudragitRL 100 as polymers were prepared successfully by quasi-emulsion solvent diffusion method. These formulations were studied for particle size, production yield and loading efficiency. The physical characterization showed that microsponge formulation F4 showed a better loading efficiency and production yield. This microsponge formulation was entrapped in carbopol gel and studied for pH, viscosity, drug content and in vitro release. Microsponge gel batch (MG 2) showed maximum viscosity 5380 cps, drug content of (98.61 %.) and appropriate drug release profile (98.70% in 12 hrs.)
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